Education/Training
- 1989: Pathophisiology Degree - Medicine and Surgery, University of Siena, Italy.
- 1993: Radiology Specialist - University of Siena, University of Siena, Italy.
- 2016: Neuroradiology - Affiliation for Professor of Neuroradiology.
Research and Professional Experience
- 1990-1993: SIUMB Italian Society of Sonography; Diploma in Lectureship in Internist Ultrasound.
- 1991-1992: Active Substitute - Doctor On Call, USL30 Sienese Area, Local Healthcare Units of the Tuscan Region, Night and holiday urgent care provider (386 hr. on call – 162 hr. active care provider).
- January 1991-January 1992: Grant Recipient in Ultrasound and Integrated Imaging - University of Siena, Italy. Department of Radiology, “Santa Maria alle Scotte” Hospital, Resident physician, execution of assistance activities.
- September 1992-April 1993: Medical Assistant in Diagnostic Radiology - USL30 Senese Area, Santa Maria alle Scotte Hospital, Medical Assistent in the Radiology Department, with night and holiday on call shifts.
- September-November 1994: Ambulatory Specialist Work - USL30 Senese Area Local Healthcare Units of the Tuscan Region Assignment of substitution.
- July 1995-September 1998: University Technical Assistant - University of Siena, Institute of Radiology and Eidological Science, Santa Maria alle Scotte Hospital, Assistance and Research Role.
- 1994-1995: Invest in Youth” Program with the European Commission ECR’95; Competition winner with the work “MR Imaging of prostate cancer: a comparison of endorectal surface coil MR imaging and Body-coil imaging with transrectal ultrasonographic imaging”.
- Settember-October 1996: European Association of Radiology – Exchange Program; As Junior Radiologist employed in the diffusion of experiences between Eastern and Western Europe: University of Siena-University of Iasi, Romania. Certificate of attendance.
- June 8-12/ 1998:Institute of Bio-Engineering, Zurich, Switzerland - Magnetic Resonance Spectroscopy: In-depth analysis of the physical and biochemical foundations, in order to optimize the clinical application of MR spectroscopy.
- September 1998-present: Medical Assistant with highly specialized professional role, University of Siena General Hospital – Santa Maria Scotte, Siena Italy. (Highly specialized healthcare company, Assistance and Research tasks in collaboration with regional, national and international interdisciplinary protocols.)
- 2009-2018: Taught Neuroradiology at the school of specialization in Medical Genetics and Department of Medicine and Surgery, University of Siena.
Research interests
- Her Research focus lies in the fields of neuroimaging/magnetic resonance imaging-based techniques, especially applications of brain perfusion, diffusion-weighted imaging, i.e. DTI, MRspectroscopy for the in vivo characterization of specific alterations of the brain in various neurodegenerative disorders. The focus is on the standardized definition of structural and functional neuroanatomical changes for their use as surrogate markers of the disease. These research efforts are directed at translating the computerized MRI techniques into a standardized application as biomarkers in studies which aim at preventive strategies in neurodegenerative, brain tumor and other neurological diseases, by focusing on early or even preclinical diagnosis and on monitoring disease-modifying interventions. The research focuses on clinical and translational neuroimaging research within the fields of neurovascular disease and cerebrospinal fluid disorders. Cerebrovascular disorders. Cerebral hemodynamics.
- Other research interests are advanced imaging techniques in pediatric population, Cerebral Tendineous Xantomatosis, brain tumor and magnetic neurostimulation.
- Sprugnoli G*, Monti L*, Lippa L, Neri F, Mencarelli L, Ruffini G, Salvador R, Oliveri G, Batani B, Momi D, Cerase A, Pascual-Leone A, Rossi A, Rossi S, Santarnecchi E. Reduction of intratumoral brain perfusion by noninvasive transcranial electrical stimulation. Sci Adv. 2019 Aug 14;5(8):eaau9309.
- Messa LV, Ginanneschi F, Momi D, Monti L, Battisti C, Cioncoloni D, Pucci B, Santarnecchi E, Rossi A. Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease. Front Hum Neurosci. 2019 Oct 15;13:350.
- Andreini I, Arrigucci U, Monti L, Bellini M, Battisti C, Federico A. A case of pneumocephalus as complication of ozone therapy: diagnosis and treatment. Neurol Sci. 2019 Sep 2.
- Zini C, Notaro D, Sadotti G, Zini G, Monti L, Bellini M. Percutaneous Intervertebral Disc Coagulation Therapy (PDCT) by Plasma Light: Preliminary Data from the First Experience in Europe. Cardiovasc Intervent Radiol. 2020 Jan;43(1):94-102.
- Ulivelli M, Monti L, Ballerini M, Bartalini S, Cerase A, Cecconi F, Pizzirusso G, Bezzini D, Rossi A, Rossi S. Prospective study of clinical, neurophysiological and urodynamic findings in multiple sclerosis patients undergoing percutaneous transluminal venous angioplasty. Clin Neurophysiol. 2019 Jan;130(1):138-144.
- Morello A, Casseri T, Acampa M, Galluzzi P, Cerase A, Monti L. Stroke in Pregnancy and Review of Current Literature: Arterial Spin-Labeling MRI Can Identify the Presence and Intensity of Collateral Circle. J Stroke Cerebrovasc Dis. 2018 Dec;27(12):3575-3577.
- Monti L, Morbidelli L, Rossi A. Impaired Cerebral Perfusion in Multiple Sclerosis: Relevance of Endothelial Factors. Biomark Insights. 2018 May 18;13:1177271918774800.
- Taglia I, Di Donato I, Bianchi S, Cerase A, Monti L, Marconi R, Orrico A, Rufa A, Federico A, Dotti MT. AARS2-related ovarioleukodystrophy: Clinical and neuroimaging features of three new cases. Acta Neurol Scand. 2018 Oct;138(4):278-283.
- Mignarri A, Carecchio M, Del Puppo M, Magistrelli L, Di Bella D, Monti L, Dotti MT. SPG5 siblings with different phenotypes showing reduction of 27-hydroxycholesterol after simvastatin-ezetimibe treatment. J Neurol Sci. 2017 Dec 15;383:39-41.
- Monti L, Morbidelli L, Bazzani L, Rossi A. Influence of Circulating Endothelin-1 and Asymmetric Dimethylarginine on Whole Brain Circulation Time in Multiple Sclerosis. Biomark Insights. 2017 Jun 6;12:1177271917712514.
- Monti L, Servillo R, Grazzini I, Khader L, Acampa M, Cerase A. Neuroimaging of Takayasu Arteritis in a Patient with Ulcerative Rectocolitis. J Stroke Cerebrovasc Dis. 2017 Jul;26(7):e129-e132.
- Mignarri A, Dotti MT, Federico A, De Stefano N, Battaglini M, Grazzini I, Galluzzi P, Monti L. The spectrum of magnetic resonance findings in cerebrotendinous xanthomatosis: redefinition and evidence of new markers of disease progression. J Neurol. 2017 May;264(5):862-874.
- Rosini F, Pretegiani E, Mignarri A, Optican LM, Serchi V, De Stefano N, Battaglini M, Monti L, Dotti MT, Federico A, Rufa A. The role of dentate nuclei in human oculomotor control: insights from cerebrotendinous xanthomatosis. J Physiol. 2017 Jun 1;595(11):3607-3620.
- Galluzzi P, de Jong MC, Sirin S, Maeder P, Piu P, Cerase A, Monti L, Brisse HJ, Castelijns JA, de Graaf P, Goericke SL. MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part I, the solid gland. European Retinoblastoma Imaging Collaboration (ERIC). Neuroradiology. 2016 Jul;58(7):705-12.
- Galluzzi P, Hadjistilianou T, Cerase A, Toti P, Leonini S, Bracco S, de Francesco S, Galimberti D, Balducci D, Piu P, Monti L, Bellini M, Caini M, Rossi A. MRI helps depict clinically undetectable risk factors in advanced stage retinoblastomas. Neuroradiol J. 2015 Feb;28(1):53-61. doi: 10.15274/NRJ-2014-10103. PMID: 25924174.
- Monti L, Donati D, Menci E, Cioni S, Bellini M, Grazzini I, Leonini S, Galluzzi P, Severi S, Burroni L, Casasco A, Morbidelli L, Santarnecchi E, Piu P. Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography. PLoS One. 2015 Feb 13;10(2):e0116681. doi: 10.1371/journal.pone.0116681. eCollection 2015.
- Rosini F, Rufa A, Monti L, Tirelli L, Federico A. Adult-onset phenylketonuria revealed by acute reversible dementia, prosopagnosia and parkinsonism. J Neurol. 2014 Dec;261(12):2446-8. doi: 10.1007/s00415-014-7492-7. Epub 2014 Oct 31. No abstract available.
- Mignarri A, Battistini S, Tomai Pitinca ML, Monti L, Burroni L, Ginanneschi F, Ricci C, Bavazzano A, Federico A, Restagno G, Dotti MT. Double trouble? Progranulin mutation and C9ORF72 repeat expansion in a case of primary non-fluent aphasia. J Neurol Sci. 2014 Jun 15;341(1-2):176-8. doi: 10.1016/j.jns.2014.03.030. Epub 2014 Mar 19. No abstract available.
- Mignarri A, Malandrini A, Del Puppo M, Magni A, Monti L, Ginanneschi F, Tessa A, Santorelli FM, Federico A, Dotti MT. Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism. J Neurol. 2014 Mar;261(3):617-9. doi: 10.1007/s00415-014-7253-7. Epub 2014 Feb 8.
- Battisti C, Di Donato I, Bianchi S, Monti L, Formichi P, Rufa A, Taglia I, Cerase A, Dotti MT, Federico A. Hereditary diffuse leukoencephalopathy with axonal spheroids: three patients with stroke-like presentation carrying new mutations in the CSF1R gene. J Neurol. 2014 Apr;261(4):768-72. doi: 10.1007/s00415-014-7257-3. Epub 2014 Feb 16.
- Monti L, Menci E, Piu P, Leonini S, Arrigucci U, Bellini M, Zandonella A, Galluzzi P, Casasco A. A sonographic quantitative cutoff value of cerebral venous outflow in neurologic diseases: a blinded study of 115 subjects. AJNR Am J Neuroradiol. 2014 Jul;35(7):1381-6. doi: 10.3174/ajnr.A3864. Epub 2014 Mar 7.
- Mencarelli MA, Tassini M, Pollazzon M, Vivi A, Calderisi M, Falco M, Fichera M, Monti L, Buoni S, Mari F, Engelke U, Wevers RA, Hayek J, Renieri A. Creatine transporter defect diagnosed by proton NMR spectroscopy in males with intellectual disability. Am J Med Genet A. 2011 Oct;155A(10):2446-52. doi: 10.1002/ajmg.a.34208. Epub 2011 Sep 9.
- Monti L, Menci E, Ulivelli M, Cerase A, Bartalini S, Piu P, Marotti N, Leonini S, Galluzzi P, Romano DG, Casasco AE, Venturi C. Quantitative ColourDopplerSonography evaluation of cerebral venous outflow: a comparative study between patients with multiple sclerosis and controls. PLoS One. 2011;6(9):e25012. doi: 10.1371/journal.pone.0025012. Epub 2011 Sep 22.
- Acampa M, Tassi R, Guideri F, Marotta G, Monti L, Capannini G, Cerase A, Martini G. Safety of intravenous thrombolysis in ischemic stroke caused by left atrial myxoma. Curr Drug Saf. 2011 Nov 1;6(5):343-5.
- Quadri M, Federico A, Zhao T, Breedveld GJ, Battisti C, Delnooz C, Severijnen LA, Di Toro Mammarella L, Mignarri A, Monti L, Sanna A, Lu P, Punzo F, Cossu G, Willemsen R, Rasi F, Oostra BA, van de Warrenburg BP, Bonifati V. Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet. 2012 Mar 9;90(3):467-77. doi: 10.1016/j.ajhg.2012.01.017. Epub 2012 Feb 16.
- Monti L, Romano DG, Gozzetti A, Di Pietro G, Miracco C, Cerase A. Myelodysplasia presenting as thoracic spinal epidural extramedullary hematopoiesis: a rare treatable cause of spinal cord myelopathy. Skeletal Radiol. 2012 May;41(5):611-4. doi: 10.1007/s00256-011-1268-2. Epub 2011 Sep 13.
- Galluzzi P, De Francesco S, Giacalone G, Cerase A, Monti L, Vallone IM, Lazzeretti L, Venturi C, Hadjistilianou T. Contrast-enhanced magnetic resonance imaging of fibrovascular tissue ingrowth within synthetic hydroxyapatite orbital implants in children. Eur J Ophthalmol. 2011 Sep-Oct;21(5):521-8. doi: 10.5301/EJO.2011.6298.
- Rufa A, Cerase A, Annunziata P, De Santi L, Buccoliero R, Monti L, Federico A. Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem. Neurol Sci. 2010 Oct;31(5):653-5. doi: 10.1007/s10072-010-0339-9. Epub 2010 Jun 11.
- Tassini M, Zannolli R, Buoni S, Engelke U, Vivi A, Valensin G, Salomons GS, De Nicola A, Strambi M, Monti L, Morava E, Wevers RA, Hayek J. Magnetic resonance spectroscopy of urine: diagnosis of a guanidinoacetate methyl transferase deficiency case. J Child Neurol. 2010 Jan;25(1):98-101. doi: 10.1177/0883073809336120. Epub 2009 May 21.
