Prathab Balaji Saravanan

PUBLICATIONS

• Saravanan PB, Vasu S, Yoshimatsu G, Darden C, Wang X, Gu J, Lawrence M, and Naziruddin B., Differential expression and release of exosomal miRNAs by human islets under inflammatory and hypoxic stress., Diabetologia, 2019, October, 62(10):1901-1914. 
  
• Saravanan PB, Kanak MA, Chang CA, Darden C, Yoshimatsu G, Lawrence MC, Naziruddin B., Islet Damage during Isolation as Assessed by miRNAs and the Correlation of miRNA Levels with Posttransplant Outcome in Islet Autotransplantation, Am J Transplant, 2018, April, 18(4):982-989. (Citations: 7)
• Yoshimatsu G, Kunnathodi F, Saravanan PB, Shahbazov R, Chang C, Darden CM, Zurawski S, Boyuk G, Kanak MA, Levy MF, Naziruddin B, Lawrence MC., Pancreatic ß-Cell-Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation, Diabetes, 2017, November, 66(11):2857-2867.(Citations: 9)
• Saravanan PB, Loganathan G, Naziruddin B, Balamurugan AN., Clinical Islet Cell transplantation- recent advances, Current Science, 2017, 113(7), 1267. (Citations: 2)
• Nayak DK, Saravanan PB, Bansal S, Naziruddin B, Mohanakumar T., Autologous and Allogenous Antibodies in Lung and Islet Cell Transplantation, Front Immunol, 2016,December, 23;7:650.  (Citations: 4)
• Yoshimatsu G, Takita M, Kanak MA, Haque WZ, Chang C, Saravanan PB, LawrenceMC, Levy MF, Naziruddin B., MiR-375 and miR-200c as predictive biomarkers of isletisolation and transplantation in total pancreatectomy with isletautotransplantation, J Hepatobiliary Pancreat Sci, 2016, September, 23(9):585-94.(Citations: 10)
• Prathab Balaji S, Vijay Chand C, Justin A and Ramanathan M., Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-? agonism via SARM and MyD88 signaling, Pharmacol Biochem and Behav, 2015, October; 137:60-8. (Citations: 21)
• Saravanan PB, Shanmuganathan MV and Ramanathan M., Telmisartan attenuated LPS-induced neuroinflammation in human IMR-32 neuronal cell line via SARM in AT1R independent mechanism, Life Sciences, 2015,June, 1;130:88-96. (Citations: 10)
• Prathab Balaji. S and Ramanathan. M., Telmisartan protects the Lipopolysaccharide Intoxicated Raw 264.7 Cell Line by Deactivating NF?B Mediated Inflammatory Mechanism, J Pharm sci & Res, 2013, 6, 68-72. (Citations: 2)
• Ravichandran Ranjithkumar, Prathab Balaji. S, Bhaskar Balaji, R V Ramesh and Ramanathan M., Standardized aqueous Tribulus terristris (Nerunjil) extract attenuates Hyperalgesia in experimentally induced diabetic neuropathic pain model: Role of Oxidative Stress and Inflammatory Mediators, Phytother Res, 2012, November, 27(11):1646-57. (Citations: 17)

SCIENTIFIC CONFERENCE ABSTRACT PUBLICATIONS

• Saravanan P, Kanak MA, Vasu S, Lawrence M, Levy M and Naziruddin B, Exosomes carry stress and damage specific miRNAs during the peritransplant period in TPIAT,Am J Transplant, 2019, April, 19:637
  
• Saravanan P, Kanak MA, Yoshimatsu G, Darden C, Lawrence M, Levy M and Naziruddin B, Analysis of islet exosomal miRNAs released post-transplant in response to inflammation,Am J Transplant, 2019, April, 19:633
• Saravanan P, Kanak MA, Yoshimatsu G, Darden C, Lawrence M, Levy M and Naziruddin B, Role of NF-KB in release of isletokines via exosomes in response to islet stress,., Am J Transplant, 2019
• Kanak MA, Saravanan P, Kalivarathan J, Shindo Y, and Levy MF, Predicting metabolic outcomes in islet autotransplantation before transplantation,., Am J Transplant, 2019, April, 19:1131-32
• Saravanan P, Yoshimatsu G, Battacharjee R, Chang C, Darden C, Naziruddin B and Lawrence M,  Identification of exosomal isletokines released by pancreatic islets in response to inflammatory stress,Am J Transplant, 2018, June, 18:251-252
• Yoshimatsu G, Darden C, Kumano K, Chang C, Saravanan P, Lawrence M and Naziruddin B, NFkB inhibitor improves glycemic control after syngenic islet transplantation by suppression of proinflammatory and apoptotic gene expression in a cerulein induced pancreatitis model, Am J Transplant, 2018, June, 18:250-251
• Saravanan P, Nguyen P, Yoshimatsu G, Chang C, Darden C, Battacharjee R, Wang X, GU J,  Lawrence M and Naziruddin B, Stress-related exosomal MicroRNA biomarkers released by human islets during transplantation, , Am J Transplant, 2018, June, 18:492
• Saravanan P, Kanak M, Yoshimatsu G, Lawrence M, and Naziruddin B, Assessment of islet damage during isolation utilizing miRNAs and its significance with post- transplant outcome in TPIAT, Am J Transplant, 2017, April, 17:350-351
• Saravanan P, Gu J, Wang X, Nguyen P, Yoshimatsu G, Lawrence M, and Naziruddin, Next-Generation sequencing based exosome MicroRNA profiling for the specific identification of Islet damage, Am J Transplant, 2017, April, 17:723
• Yoshimatsu G, Chang C, Darden C, Saravanan P, Naziruddin B, and Lawrence M, IP-10 monoclonal antibody treatment suppresses inflammatory components of IBMIR and improves pancreatic islet graft function, Am J Transplant, 2017, April, 17:714
• Chang C, Yoshimatsu G, Saravanan P, Lawrence M, Kane R, and Naziruddin B, TAK-242, a small molecule TLR4 antagonist, improves the outcome and function of transplanted islets, Diabetes, 2016, June, 65(A84)
• Darden C, Saravanan P, Yoshimatsu G, Boyuk G, Chang C, Naziruddin B, and Lawrence M, Regulation of glucagon gene expression by calcineurin/NFAT and ERK1/2 signaling, Diabetes, 2016, June, 65(A539)
• Yoshimatsu G, Takita M, Shahbazov R, Chang C, Saravanan PB, Kanak M, Lawrence M, Kim P, Onaca N, Naziruddin B, and Levy M, Comparison of outcomes from patient with prior surgery in total pancreatectomy with islet autotransplanation for refractory chronic pancreatitis: A single –Institution experience with 120 consecutive cases, Gastroenterology, 2016, April, 150(4), S909
• Yoshimatsu G, Takita M, Saravanan PB, Chang C, Darden C, Kanak M, Saracino G, Lawrence M, Kim P, Levy M, and Naziruddin B, A novel set of microRNA biomarkers can predict outcomes of pancreatic islet isolation and graft function following autologous islet transplantation for the refractory chronic pancreatitis, Gastroenterology, 2016, April, 150(4), S909
• Saravanan P, Darden C, Yoshimatsu G, Boyuk G, Chang C, Lawrence M, and Naziruddin B, Exosomal compartmentalization and release of microRNA375 from human pancreatic islets, American Diabetes Association’s 76th Scientific Sessions, 2016
• Darden C, Saravanan P, Yoshimatsu G, Chang C, Boyuk G, Naziruddin B, and Lawrence M, Induction of alpha-cell differentiation from islet derived mesenchymal stem cells by a calcineurin and NFATc2 pathway, American Diabetes Association’s 76th Scientific Sessions, 2016
• Lawrence M, Yoshimatsu G, Saravanan P, Chang C, Darden C, Boyuk G, and Naziruddin B, Calcineurin and NFAT mediate islet inflammation by regulation of CXCL10/IP-10 gene expression and secretion in pancreatic beta cells, American Diabetes Association’s 76th Scientific Sessions, 2016
• Saravanan P, Kanak M, Yoshimatsu G, Chang C, Levy M, Lawrence M, and Naziruddin B, High resolution detection of islet damage ny microRNA-375 during and after human isolation procedures, Xenotransplantation, 2015, November, (22)
• Saravanan P, Nofit Borenstein-Auerbach, Kanak M, Chang C, Yoshimatsu G, Levy M, Naziruddin B, and Lawrence M, Engineering neoislets from islet-derived mesenchymal stem cells, Xenotransplantation, 2015, November, (22)
• Yoshimatsu G, Takita M, Kanak M, Khan O, Chang C, Saravanan P, Shahbazov R, Levy M, Naziruddin B, and Lawrence M, Pancreas derived mesenchymal stem cell improve the glucose response of transplanted islets more effectively than adipose tissue derived stem cells, Xenotransplantation, 2015, November, (22)
• Kanak M,Borenstein-Auerbach N, Chang C, Shahbazov R, Yoshimatsu G, Saravanan P, Takita M, Levy M, Naziruddin B, and Lawrence M, Pancreatic beta cell expression of IFN-gamma-inducible protein 10 (IP-10/CXCL10) in response to islet cell stress is required for early islet graft loss of function, Xenotransplantation, 2015, November, (22)

CURRENT RESEARCH FOCUS

• Clinical islet transplantation is the best treatment option to restore the normoglycemia and good quality of life in patients with type 1 diabetes (T1D) and chronic pancreatitis (CP). So far I was successfully involved in more than 100 clinical autologous islet transplantation procedure. 
• During islet transplantation, about 50% of transplanted islets undergo immediate damage during peri-transplant period and moreover, the long term survival of graft is highly compromised due to various factors like IBMIR, hypoxic, innate and post-transplant immune reactions, etc. Thus, my current research focuses mainly on developing strategies to improve islet graft viability and function after transplantation. 
• Since, Islet cells release miRNAs, long non-coding RNAs, extracellular vesicles and exosomes as representative molecules during various steps in transplantation and also during numerous pathological conditions, my research also focusing on identification of reliable markers and ultrasensitive assays to assess islet stress and damage.