Jianmin Qin, MD presently working as a Professor in the Department of General Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Military Medical University, 225 Changhai Road, Shanghai, China.
Jianmin Qin mainly engaged in surgical treatment of hepatobiliary and pancreatic tumors, as well as the prevention and treatment of recurrence and metastasis of tumors after surgery.
Jianmin Qin has over 20 years of experience in the research, discovery and business development of medications aimed to treat the hepatocellular carcinoma. Notably, He had authored more than 120 manuscripts, 6 patents, and co-edited "Targeted drug therapy for hepatocellular carcinoma".
- Interventional therapy for digestive tumors: I have engaged in manufacturing the arterial embolism agent as a assistant research fellow from Jul.1994 to Aug.1997. I have successfully manufactured the degradable starch microspheres(DSMs) with the help of physical chemist for 3 years .As a new degradable embolism agent, can be used to treat about digestive tumors such as stomach, liver and intestine.
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Pathogenesy of acute liver failure: I have engaged in the basic research for acute liver failure as a assistant research fellow from Jul.1997 to Aug.2000.nitric oxide(NO) , as a preinflammatory factor and signal transduction messenger , plays an important role in acute liver failure after partial hepatectomy , especially participating in multiple organ dysfunction such as liver, lung, kidney, intestine etc . By interfering with NO production , MODS can significantly be prevented or decreased.
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Signal transduction pathway of hepatocellular carcinoma: I have engaged in signal transduction pathway of tumor as associate investigator from Aug.2000 to Sep.2003.Signal regulatory protein alpha(Sirpa), as a inhibitor factor and member of signal regulatory proteins, is involved in liver regeneration after partial hepatectomy, mainly participating in liver regeneration termination . Sirpa is associated with occurrence and development of hepatocellular carcinoma , the low expression of Sirpa is contributive to occurrence and development of hepatocellular carcinoma by increasing the expression of nuclear factor ?B (P65 and P50). now the correlation between Sirpa and immune rejection is being done a research after liver transplantation.
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Drug targeting therapy for hepatocellular carcinoma: I have engaged in manufacturing the drug targeting agents as research fellow from Aug.2000 to Sep.2003.I have successfully manufactured the immune nanoparticles of brucine , as a target therapeutic drug , induced apoptosis of liver cancer cells and inhibited the growth of liver cancer cells by high protein and mRNA expression of Fas . it is potential development drug for hepatocellular carcinoma .
- X Sheng, PF Zhu, JM Qin, et al. The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin. Oncology Reports,2018,39(6):2931-2941.
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JM Qin, L Yang,X Sheng, et al.Antitumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma in vivo. Oncology Letters,2018,15(5):6137-6146.
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Sheng X, Huang T, Qin J, et al. Identification of the Differential Expression Profiles of Serum and Tissue Proteins During Rat Hepatocarcinogenesis. Technol Cancer Res Treat. 2018,17:1-13.
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Qin JM, Selection and clinical significance of individualized treatment for metastatic liver cancer, World Chin J Digest,2018,26(29):1677-1687.
- X Sheng, T Huang, JM Qin,et al. Preparation, pharmacokinetics, tissue distribution and antitumor effect of sorafenib incorporating nanoparticles in vivo.Oncology Letters,2017,14(5):6163-6169.
- ShengX, Zhu PF, Qin JM. Study of the Biological Effect of Bufalin on Anti-Proliferation, Adhesion and Invasion in Liver Cancer Cells.Clinics in Surgery, 2017,2(22):1-5.
- JM Qin,XG Gu, Z Wang,et al. Indication and Clinical Treatment of Minimally Invasive Therapy for Postoperative Recurrence of primary Liver Cancer or Metastatic Liver Cancer. J Hepatopancreatobiliary Surg, 2016,6:81-85.
- X Sheng,XT Sun,Kang Sun,et al. Inhibitory effect of bufalin combined with Hedgehog signaling pathway inhibitors on proliferation and invasion and metastasis of liver cancer cells.Int J Oncol,2016,49:1513-1524.
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GaiJQ,ShengX,QinJM,etal.The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/ß-catenin signaling pathway. Int J Oncol,2015,18 :338-348.
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Jianmin Qin,Xingang GU. Application value of enhanced ultrasonography in early diagnosis and treatment for liver cancer.J Hepatopancreatobiliary Surg,2015,1:75-78.
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Jianmin Qin,Xingang Gu.Application value of evidence -based medicine in qualitatively diagnosing the focal liver lesion.Chin Continuing Med Education,2015,7:62-66.
- Jianmin Qin,Lei Ni,Wei Zhao, et al.Operational management and complication prevention of laparoscopic cholecystectomy for gangrenous cholecystitis caused by incarcerated:report of 36 case.Chin J Min lnv Surg,2015,6:505-508.
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Pengfei Zhu,Jianmin Qin,Role of cell autophagy in invasion and metastasis of hepatocellular carcinoma.World Chin J Digest,2015,13:2029-2035.
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Kang Sun,Jianmin Qin,Biological function of Hedgehog signal pathway in occurrence and development of liver cancer.J Surg. Concepts Pract.2015,2:87-89.
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Pengfei Zhu,Jianmin Qin,Biological function of autophagy in occurrence and prevention of prim ary liver cancer.Chin Med & Pharmacy,2015,4:24-28.
- Jingchang, Kang Sun,Xia Sheng, Jianmin Qin. Study of bufalin on anti-proliferation and apoptosis of high metastasis liver cancer cells.Chin J Exp.Surg.,2015,1:2388-2391.
- Kang Sun,Jianmin Qin,Study of bufalin on the apoptotic mechanism of liver cancer cells.J Hepatopancreatobiliary Surg,2014,5:396-398.
- Jianmin Qin, Tao Huang, Xia Sheng, et al. Experimental study of inhibitive efect of sorafenib combined with dendritic cells and cytokine induced killer cells on hepatocellular carcinoma. J Hepatopancreatobiliary Surg,2014,2:148-151.
- Jiqin Gai,Jianmin Qin,Yuezu Fan. Bufalin inhibits proliferation and invasion of hum an liver cancer cell.World Chin J Digest,2014:14:1921-1927.
- Wei zhao,Teng Chen,Jianmin Qin,et al. Comparative study on the emergency operation and selective operation in treatment the patients with portal hypertension complicated by upper gastrointestinal bleeding.Chin J Physician Education,2014,14:25-27.
- Jianmin Qin, Tao Huang, Xia Sheng, et al.Effect of sorafenib combined with dendritic cells and cytokine induced killer cells on anti-tumor growth and invasion and matastasis in hepatocellular carcinoma.Chin J Digestive Surg,2014, 5:363-368.
- Jianmin Qin, Wen Yu,Teng Chen. Exploration into teaching mode for western surgery for integration of chinese medicine with medicine in University of Traditional Chinese Medicine.J Chin Med Edu Techno,2014,1:93-95.
- Jianmin Qin, Peihao Yin, Min Zhang,et al. Application of Case-Based Learning in clinical clerkship of hepatobiliary surgery.Chin J Med Edu Res ,2013,6:603-605.
- Jianmin Qin, Peihao Yin, Qi Li,et al. Application and significance of PBL teaching model in scientific research of postgraduate of general surgery in University of Traditional Chinese Medicine and Pharmacy.J Health Vocational Education,2013,7:8-9.
- Jianmin Qin, Peihao Yin, Wen Yu,et al. Exploration into teaching mode for western surgery in University of Traditional Chinese Medicine and Pharmacy.J Northwest Med Edu,2013,2:372-375.
- Jianmin Qin, Xingang Gu, Min Zhang, et al. Application of contrast enhanced ultrasonography in microwave ablation for liver cancer. J Hepatopancreatobiliary Surg,2013,1:27-30.
- Jiqin Gai,Jianmin Qin, Yuezu Fan. Study on the therapeutic effect and mechanism of bufalin for hepatocellular carcinoma.Chin Med.and Pharmacy,2013,1:60-62.
- Yang Wu,Xingang Gu,Jianmin Qin, et al.Clinical significance of sclerous treatment for diabetes mellitus patients with hepatic cyst under the ultrasonic guidance.J Med Frontier,2013,3:108-109.
- Jian-min Qin, Pei-hao Yin, Qi Li, et al.Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma.Int J Nanomedicine,2012,7:369-379.
- Wenxiang Zhi,Xingang Gu, Jianmin Qin, et al. Solid Breast Lesions: Clinical Experience with US-guided Diffuse Optical Tomography Combined with Conventional US.Radiology,2012,2:371-378.
- Jianmin Qin,Yang Lin,Zhongqiu Sa,et al. Preparation of Brucine Immuno-nanoparticles and Study on the Pharmacokinetics in Vivo.J Clin Rehabilitative Tissue Engineering Res,2012,29:5331-5339.
- Jianmin Qin,Xia Sheng,Lin Yang,et al. The Clinical Study on the Effect of IL-10 and IL-12 in postoperative Colorectal Cancer with Liver Metastasis. J Hepatobiliary Surg,2012, 2:116-119.
- Jianmin Qin,Yang Lin,Xia Sheng, et al.Changes of hepatic pathology and AFP level during hepatic cirrhosis and hepatocarcinogenesis in rat.J Hepatopancreatobiliary Surg, 2012,1:53-56.
- Jianmin Qin, Zhongqiu Sa, Xia Sheng, et al.Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma.Int J Nanomedicine,2012, 7:369-379.
- Jianmin Qin, Xingang Gu, Kang Wang, et al. Application value of contrast enhanced ultrasonography in early diagnosis for postoperative intrahepatic recurrence and metastasis in hepatocellular carcinoma.J Hepatobiliary Surg,2012,6:428-431.
- Tao Huang,jianmin Qin. Applications of immune targeting nanomedicine in the treatment of liver cancer. World Chin J Digest,2011,35:3557-3561.
- Jianmin Qin,Zhongqiu Sa,Xiajun Xu,et al.Exprimental study on the therapeutic effect of bucine nanoparticles on hepatocellular carcinoma.Chin J Hepatobiliary Surg,2011,12:1005-1008.
- Jianmin Qin,Zhongqiu Sa,Yang Lin,et al. Experimental Study on the Therapeutic Effect of Invasiveness and Metastasis of Brucine for Hepatocellular Carcinoma. J Hepatobiliary Surg,2011,5:390-392.
- Jianmin Qin,Xiajun Xu,Xia Sheng,et al. The effect of brucine on hepatocellular carcinoma cell lines in vitro. Chin J Gen Surg,2011,3:219-221.
- Lin Yang,Jianmin Qin.Non-operative therapeutic status and progression on recurrence and metastasis of primary liver cancer after operation. J Hepatopancreatobiliary Surg,2011,2:78-81.
- Tao Huang,Jianmin Qin.Effect and clinical significance of molecular targeting therapy for primary liver cancer.J Surg. Concepts Pract.2011,2:212-216.
- Jianmin Qin,Xia Sheng,Lin Yang.Study on tne correlation between dysfunction of dentritic cells and liver metastasisof colorectal carcinoma. Chin J Gen Surg, 2011,5:370-374.
- Jing Chang,Lin Yang, Jianmin Qin,et al.Effect of Nux Vomica on growth of hepatocellular carcinoma cells and action mechanis.Chin J Exp.Surg., 2011,10:1656-1658.
- Jianmin Qin,Min Zhang,Lei Kong,et al.Application of extra-amicula tumor resection in hemangiomas of liver. J Hepatobiliary Surg,2010,6:440-442.
- Jianmin Qin,Dehong Xie,Peihao Yin,et al. Indication and management of laparoscopical therapy for hepatic cyst in 36 patients. J Hepatobiliary Surg,2010,1:34-36.
- Jianmin Qin,Xia Sheng,Lin Yang,et al.Effect and clinical significance of dentritic cells and subgroup in postoperative liver metastasis after colorectal carcinoma. J Surg. Concepts Pract,2010,5:542-544.
- Lin Yang,Jianmin Qin.Recurrence and metastasis of primary liver cancer and drug targeting therapy. J Hepatobiliary Surg,2010,5:389-391.
- Zhongqiu Sa,Lei Ni, Jianmin Qin.Research progression of nanoparticles in targeting therapy for primary liver cancer. J Hepatobiliary Surg,2010,2:145-147.
- Zhongqiu Sa,Jianmin Qin,Lei Ni. Effcet of proteomics in mechanism and diagnosis and treatment for primary liver cancer.J World Chin J Digestol,2010,15:1521-1524.
- Jianmin Qin,Xingang Gu,Min Zhang, et al. Clinical characteristics and minimally invasive treatment of diabets mellitus accopanied by pyogenic hepatic abscess. J Surg.Concepts Pract,2009,6:660-663.
- Jianmin Qin,Peihao Yin, Qinyao Wang ,et al . Diagnosis and Surgical Treatment about Mirizzi Syndrome. Chin J Hepatobiliary Surg,2009,12:717-719.
- Jianmin Qin,Takada Y,Uemoto S,et al .Cause and Treatment about Biliary Duct Complication after Living Donor Liver Transplantation. Chin J Hepatobiliary Surg,2009,2:149-152.
- Jianmin Qin,Takada Y,Uemoto S,et al . Treatment and Prevention for Biliary Duct Complication after Living Donor Liver Transplantation. Chin J Hepatobiliary Surg,2008,10:684-687.
- Jianmin Qin, Takada Y, Uemoto S, et al . Present status and recent advances in living donor liver transplantation for hepatic malignant tumors. Hepatobiliary Pancreat Dis Int ,2008,2:126-134.
- Jian min Qin, Dazhi Chen . Useful value of SELDI-TOF-MS technique in liver disease proteomics. Chin J Hepatobiliary Surg,2008,1:57-59.
- Jianmin Qin, Qiang He, Dazhi Chen, et al . Clinical significance and useful value of bile duct stent in liver transplantation. Chin J Organ Transpl,2007,7: 441-442.
- Jian min Qin, Yangde Zhang, Dazhi Chen . Selection and clinical treatment for acute biliary severe pancreatitis.J Clinical Surgery,2006,5:432-435.
- Jianmin Qin, Hexin Yan, shuqin Liu , et al . Experimental study on negatively regulating mechanism of sirpa1 in hepatocellular carcinoma . HBPD Int , 2006, 2:246-251.
- Jianmin Qin, Peng Li, Jiantao Kou , et al .Clinical characteristic and surgical treatment for acute hyperlipoid pancreatitis . Chin J Hepatobiliary Surg,2006;7:489-490.
- Jianmin Qin, Zunsheng LV,Hua Fan , et al . Clinical characteristic and surgical treatment for neurofibroma of primary common hepatic duct . Chin J Hepatobiliary Surg ,2006,5:322.
- Jian min Qin, Dazhi Chen . Significance of hematopoietic stem cell in liver disease. J Hepatopancreatobiliary Surg, 2006,4:261-263.
- Jianmin Qin, Shuqin Liu, Xiangwang Wan, et al. Expression and biological significance of Sirpa1 in bile duct type hepatic carcinoma . Chin J Hepatobiliary Surg ,2006, 3:188-190.
- Jianmin Qin, Qiang He, Dazhi Chen, et al . Cause and operative opportunity of liver retransplantation Chin J Gen Surg , 2006,1:22-24.
- Hua Fan, Jianmin Qin, Qiang He,et al . Diagnosis and treatment for fungus infection after liver transplantation . Chin J Organ Transpl, 2006,5:280-282.
- Zunsheng LV, Dazhi Chen, Jianmin Qin, et al. Establishment of ischemic bile duct stricture model of mice by ring clamp manoeuvre . Chin J Hepatobiliary Surg , 2006,6:419-421.
- Jianmin Qin, Hexin Yan, Xingwang Wan , et al . Preliminary study on the effective mechanism of signal regulatory proteina1 on protein proliferating control of hepatocellular carcinoma . HBPD Int, 2005,4:244-248.
- Jianmin Qin, Yangde Zahng, Bowen Wu, et al . Surgical treatment for primary liver carcinoma with portal hypertension . J Hepatopancreatobiliary Surg, 2005,2:139-141.
- Jianmin Qin, Qiang He , Dazhi Chen, et al . Diagnosis and treatment of bile duct stricture after liver transplantation . Chin J Organ Transpl,2005,10:631-632.
- JianMin Qin, Mengshang Zhang, Yangde Zhang, et al . Diagnosis and treatment about primary gallbladder carcinoma with bile duct obstruction. J Hepatobiliary Surg, 2005,10:565-567.
- Shuqin Liu, JianMin Qin, Jinzhang Zeng , et al .Preparative technique of whole paraffin specimen in various stage mouse embryo . J Anatomy, 2005,6:721-723.
- JianMin Qin, Shenjing Li, ShuQin Liu, et al . Effects of SIRPa1 on liver regeneration in rat . J Surg Res ,2004,117:216-222.
- Xiaoyong Fu, Lu Tan, Shuqin Liu, Honghai Li, Lei Chen, Jianmin Qin ,et al . A novel diagnostic marker, p28GANK distinguishes hepatocellular carcinoma from potential mimics. J Cancer Res Clin Oncol,2004,10:1007-1014.
- Jianmin Qin, Shuqin Liu, Jinzhang Zeng , et al . Gene expression and significance of Gankyrin in organs and tissues during mouse embryogenesis .J Med Coll PLA Univ ,2004,4:201-204.
- Jianmin Qin, Shuqin Liu ,Jinzhang Zeng ,et al . Experimental study on expression of Transforming growth factorß1 in rat liver regeneration. Chin J Gen Surg, 2004,3:180-181.
- Jianmin Qin , Yangde Zhang , Bowen Wu , et al . Diagnosis and treatment of small hepatocellular carcinoma with negative Alpha fetal protein. Chin J Hepatobiliary Surg , 2004,8: 647-680.
- Jianmin Qin , Yangde Zhang , Hongyang Wang, et al .Usage and progress of nanodrug in hepatic disease. Chin J Hepatobiliary Surg , 2004, 10: 864-867.
- Jianmin Qin, Guangjin Liu, Yangde Zhang , et al . Clinical treatment for cholelithasis with portal hypertension . J Clin Surg ,2004,7:67-70.
- JianMin Q, Shenjing L, ShuQin L, et al .Gene and protein expressions of Gankyrin in rat with liver regeneration . World J Gastroenterology , 2003,11:2523-2527.
- Shenjing Li, Jianmin Qin, Xiaobo Man, et al . Aukyratic expression of gpc3/mxr7 gene and preparation of its polycolonal antibody. Chin J Mod Med , 2003,4:95-98.
- Jianmin Qin, Yangde Zhang, Hongyang Wang, et al . Nanotechnology usage in diagnosis and treatment of liver diseases. Chin J Mod Med ,2003,2:4-7.
- Jianmin Qin, Yangde Zhang . Expression of nitric oxide synase in major organs of acute liver failure rat . Acad J Sec Mil Med Univ , 2002,9:1003-1006.
- Jianmin Qin , Shuqin Liu, Xiuhua Qiu, et al . Experimental study on regulatory control of signal regulatory protein a1 in rat liver regeneration. Chin J Exp Surg, 2002,6:341-343.
- Jianmin Qin, Hongyang Wang, Mengchao Wu . Regulatory and control of cytokines during liver regeneration . Chin J Hepatobiliary Surg , 2002, 6:375-379.
- Jianmin Q,Yangde Z .Gene expression of eNOSmRNA and iNOSmRNA in intestine of rat ALF.World J Gastroenterology ,2001,11:652-656.
- Yangde Zhang , Jianmin Qin ,Jian Peng . Experimenatl study on expression of eNOSmRNA and iNOSmRNA in ALF rat.. Chin J Mod Med , 2001,5:1-3.
- Jianmin Qin , Yangde Zhang . Experimental study on effect of nitric oxide on multiple organs in acute liver failure. Chin J Hepatol ,2001,6:377.
- Yangde Zhang , Jianmin Qin , Jian Peng . Effect of nitric oxide on survival of rats with acute liver failure. Chin J Gen Surg, 2001,11:683-685.
- Jianmin Qin, Hongyang Wang , Mengchao Wu . Biological effect of abnormal signal transduction on occurrence and development of primary liver carcinoma. World Chin J Digestol, 2001,9:1061-1065.
- Jianmin Qin, Hongyang Wang , Mengchao Wu . Biological effect and significance of signal regulatory protein Sirps in signal transduction . For Med Sci Sec Mol Bio, 2001,1:41-44.
- Jianmin Qin , Yintai Li, Xin HU, et al . Experimental study on rabbit gastric artery embolism with CDDP-DSMS. Chin J Gen Surg, 2000.2:91-94.
- Xin Hu , Xinbo Hou , Jianmin Qin , et al . Pharmacokinetic Analysis of degradable starch microspheres . Acad J Beijing Med Univ , 2000,3:157.
- Guisheng Deng , Mengshang Zhang , Jianmin Qin. Laparoscopic cholecystectomy for 24 cases incarcerative calculous cholecystitis . Acad J Henan Med Univ , 2000,5:465-466.
- Guisheng Deng , Mengshang Zhang , Jianmin Qin. Treatment and prophylaxis of bile duct injury in Laparoscopic cholecystectomy.J Hepatobiliary Surg,2000,4:291-292.
- Jianmin Qin , Yangde Zhang , Shu Liu, et al . Early diagnosis and surgical treatment for pancreatic carcinoma.Chin J Cur Adv Gen Surg , 1999,5:42-44.
- Jianmin Qin , Yangde Zhang, Xiaoping Wan, et al . Laparoscopic surgery for calculus incarcerated cholecystitis in the cystic duct or hartmann’s pouch . J Hepatobiliary Surg ,1999,5:352-354.
- Jianmin Qin, Yangde Zhang. Treatment for 17 cases of large intestine carcinoma with diabetes mellitus . Chin J Prac Surg,1999,3:166-167.
- Jianmin Qin, yintai Li. Interventional therapy for gastric carcinoma . World Chin J Digestol,1996,3:97-101.
- Guisheng Deng, Jianmin Qin , Mengshang Zhang . Surgical treatment for large intestine carcinoma with intestine obstruction.Zhongyuan Med J ,1995,4:262-163.
